Design and Development of Tablets Containing High Amount of Polyherbal Aqueous Extract with Improved Disintegration Time Vijaya Srr, Anithakumari, Ramesh Rv and Selvakumar Duraipandi

The polyherbal decoction, Gulugulutitakam is known for the treatment of various inflammatory conditions. For the ease of administration, this dosage form has been converted into tablets containing high amount of dry extract but it has the disadvantage of longer disintegration and dissolution parameters. In our attempt to develop tablets with improved disintegration and dissolution time, we have prepared eight formulations of varying concentrations of dry extract with different excipient blends. Super disintegrants (Cros carmellose sodium, Crospovidone, sodium starch glycolate), Diluents (Dibasic calcium phosphate) were used in the formulation of tablets. We have performed the pre-compression evaluations like Angle of repose, Carr’s index and Hausner ratio to study the powder blend characteristics. We have evaluated the tablet characteristics via Friability, Hardness and Disintegration time. It was concluded that the threshold level of dry extract should be kept at 700mg/g of tablet for excipient blend of super disintegrants SSG, CCS and CP in equal parts for faster disintegration of tablets. VIJAYA SRR Ultra College of Pharmacy, Annanagar, Madurai, 625020, India PHARMACEUTICS